BDBM304121 2-(1-((4-carboxyphenyl)amino)-3-(1- cyanocyclopropyl)-1-oxopropan-2- yl)-5-(3-chloro-2-fluoro-6- (trifluoromethyl)phenyl)pyridine 1- oxide::US10143681, Example 30

SMILES OC(=O)c1ccc(NC(=O)C(CC2(CC2)C#N)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)(F)F)cc1

InChI Key InChIKey=IABKOYWFXCSAPK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304121   

TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304121(2-(1-((4-carboxyphenyl)amino)-3-(1- cyanocycloprop...)
Affinity DataIC50:  155nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304121(2-(1-((4-carboxyphenyl)amino)-3-(1- cyanocycloprop...)
Affinity DataIC50:  7.60nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent