BDBM31005 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine::MIANSERIN HYDROCHLORIDE::MLS000069681::SMR000058472::cid_68551
SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
InChI Key InChIKey=YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 31005
Affinity DataKi: 1.10nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor at 1.0 uM concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to 5-hydroxytryptamine 2 receptor in rat frontal cortical membranes by [3H]- KET displacement.More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligandMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 62nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 99nMAssay Description:Binding affinity towards alpha-1 adrenergic receptor at 1.0 uM concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 580nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 828nMAssay Description:Binding affinity towards Dopamine receptor D2 at 1.0 uM concentrationMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of serotonin (5-HT) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 4.70E+3nMAssay Description:Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine (DA) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes alpha2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:In vitro binding affinity towards alpha-adrenoceptor of calf cortex membrane Site A using [3H]clonidineMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:In vitro binding affinity of alpha-adrenoceptor by interacting with high affinity [3H]5-HT from calf caudate nucleusMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro binding affinity towards alpha-adrenoceptor of calf cortex membrane Site B using [3H]-clonidineMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:In vitro binding affinity towards alpha-adreno ceptor of rat forebrain using [3H]prazosinMore data for this Ligand-Target Pair