BDBM311130 US10155751, Example 17

SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C(C)(C)C#N)[C@H]1CNC(=O)C1

InChI Key InChIKey=SKIUGZXJAYSGSO-GDBMZVCRSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 311130   

TargetTyrosine-protein kinase SYK [342-635](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311130(US10155751, Example 17)
Affinity DataIC50:  2.90nMAssay Description:Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [564-960](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311130(US10155751, Example 17)
Affinity DataIC50:  1.13E+4nMAssay Description:Recombinant human FLT3 (amino acids 564-958, Molecular weight 48.6 kDa, Invitrogen #PR4666C) was expressed with an Histidine tag. The test compounds...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B [1-341](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311130(US10155751, Example 17)
Affinity DataIC50:  5.00E+4nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent