BDBM311139 example 3B.22 on page 219 of WO15017610

SMILES C[C@@H](Oc1cc(cc2ncn(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1

InChI Key InChIKey=KSZAIPSQJXGBNH-UKRRQHHQSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 311139   

TargetTyrosine-protein kinase SYK [342-635](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311139(example 3B.22 on page 219 of WO15017610)
Affinity DataIC50:  0.800nMAssay Description:Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [564-960](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311139(example 3B.22 on page 219 of WO15017610)
Affinity DataIC50:  307nMAssay Description:Recombinant human FLT3 (amino acids 564-958, Molecular weight 48.6 kDa, Invitrogen #PR4666C) was expressed with an Histidine tag. The test compounds...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B [1-341](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311139(example 3B.22 on page 219 of WO15017610)
Affinity DataIC50:  771nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent