BDBM320012 3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179

SMILES C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F

InChI Key InChIKey=PZDPWIRLHUGUOG-RDTXWAMCSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 320012   

TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  13nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  703nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  13nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  703nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  13nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  703nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  13nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320012(3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3-...)
Affinity DataIC50:  703nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent