BDBM321462 6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 54

SMILES Fc1ccc(cc1C(=O)N1CCOCC1)-c1cn(CCC=C)c(=O)c2[nH]ccc12

InChI Key InChIKey=OWQNTPSDYOZXJM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 321462   

TargetChromatin remodeling regulator CECR2 [424-538](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  11nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed