BDBM331840 (R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphenyl]-8-(5-fluoro-2-methyl-phenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one::US10189796, Compound 5-1::US10435379, Compound 5-1

SMILES COc1cc(OC[C@H](O)CC#N)ccc1-c1ccc2NC(C)(C)C(=O)N(C)c2c1COc1cc(F)ccc1C

InChI Key InChIKey=PRPUCYPOQXAQPA-HXUWFJFHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331840   

TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331840((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50:  14nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331840((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50:  14nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent