BDBM332858 US10196390, Compound I-147

SMILES OC1CCN(CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1

InChI Key InChIKey=CSKWMCUZWIEQHE-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 332858   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332858(US10196390, Compound I-147)
Affinity DataKi:  0.210nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332858(US10196390, Compound I-147)
Affinity DataKi: <10nMAssay Description:The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM332858(US10196390, Compound I-147)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332858(US10196390, Compound I-147)
Affinity DataIC50:  82nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed