BDBM357271 2-(((1s,4s)-4-((5- (cyanomethylthio)-3,4- diphenyl-1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid::US10214518, Compound 184::US11098034, Compound 184

SMILES OC(=O)COC[C@H]1CC[C@@H](Cn2nc(c(c2SCC#N)-c2ccccc2)-c2ccccc2)CC1

InChI Key InChIKey=DVZKKBXNFCNCGU-OYRHEFFESA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357271   

TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(2-(((1s,4s)-4-((5- (cyanomethylthio)-3,4- diphenyl...)
Affinity DataEC50:  11nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(2-(((1s,4s)-4-((5- (cyanomethylthio)-3,4- diphenyl...)
Affinity DataEC50:  11nMAssay Description:Principle of the assay: The HTRF® assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF® assay supported by the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMajor prion protein(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(2-(((1s,4s)-4-((5- (cyanomethylthio)-3,4- diphenyl...)
Affinity DataIC50:  20nMAssay Description:Blood collected from healthy human volunteers in aqueous trisodium citrate solution was centrifuged at 150 g for 15 min and the upper layer was recov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent