BDBM365127 9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)pyrimidin-4-yl)- 8,9-dihydro-1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10278975, Compound I-62S::US11376260, Example I-62R::US9867833, Compound I-62(R)

SMILES COc1ccc(C[C@@H]2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1

InChI Key InChIKey=HWMUOSSXNXZKMN-GOSISDBHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365127   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365127(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Affinity DataIC50:  44nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365127(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365127(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent