BDBM365148 N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluoromethyl)- 1H-pyrazol-1-yl)methyl)-8,9- dihydro-7H-6-oxa-1,2,2a1- triazabenzo[cd]azulen-4- yl)pyrimidin-2-amine::US10278975, Compound I-73::US10517878, Compound I-73::US10842799, I-73::US11376260, Example I-73R::US9867833, Compound I-73

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Cn3cc(cn3)C(F)(F)F)c3nnc(c1)n23

InChI Key InChIKey=LIKZYUIUGOEUPE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 365148   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365148(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365148(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365148(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365148(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365148(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent