BDBM365745 4-Amino-6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-4-hydroxy-piperidin-1-yl}-pyrimidine-5-carbonitrile::US9867826, Compound 44

SMILES Cc1cc(ccc1F)-c1cn(CCN2CCC2)c(n1)C1(O)CCN(CC1)c1ncnc(N)c1C#N

InChI Key InChIKey=QDFZHFJIXUUJBE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 365745   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM365745(4-Amino-6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluor...)
Affinity DataIC50:  5.5nMAssay Description:AKT: A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose respon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1 [T412E](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM365745(4-Amino-6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluor...)
Affinity DataIC50:  5.5nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent