BDBM370631 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 8::US10813932, Example 8::US9993478, Example 8
SMILES COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1
InChI Key InChIKey=PHWDSIFWTAWWTO-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 370631
Affinity DataIC50: 151nMAssay Description:p38 MAPKα: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do...More data for this Ligand-Target Pair
Affinity DataIC50: >1.55E+4nMAssay Description:p38 MAPKγ: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do...More data for this Ligand-Target Pair
Affinity DataIC50: >1.55E+4nMAssay Description:GSK 3α: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both donor...More data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
Affinity DataIC50: >1.55E+4nMAssay Description:GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level...More data for this Ligand-Target Pair
Affinity DataIC50: >1.55E+4nMAssay Description:The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...More data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det...More data for this Ligand-Target Pair
Affinity DataIC50: >1.55E+4nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi...More data for this Ligand-Target Pair
Affinity DataIC50: >1.55E+4nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair