BDBM383352 4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10278975, Compound I-88 R::US11376260, Example I-88R

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@H](Cc3cccc(Cl)c3)c3nnc(c1)n23

InChI Key InChIKey=SYCYKCJYHIDUFW-INIZCTEOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383352   

TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM383352(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM383352(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent