BDBM387264 N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methyl-[1,1′- biphenyl]-4-yl)-2,6- difluorobenzamide::US10292981, Example 29

SMILES Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O

InChI Key InChIKey=NFSNROSXMGPXOR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387264   

TargetNuclear factor of activated T-cells, cytoplasmic 2(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM387264(N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Affinity DataIC50: <500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-2(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM387264(N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Affinity DataIC50: <100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent