BDBM392573 N-((1-aminoisoquinolin-6-yl)methyl)- 1-((3-chloro-8-(2-hydroxypropan-2- yl)quinolin-6-yl)methyl)-3-cyano-1H- pyrazole-4-carboxamide::US10301284, Example 59::US10781200, Example 59

SMILES CC(C)(O)c1cc(Cn2cc(C(=O)NCc3ccc4c(N)nccc4c3)c(n2)C#N)cc2cc(Cl)cnc12

InChI Key InChIKey=JFMWDYUDNMXWSX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392573   

TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM392573(N-((1-aminoisoquinolin-6-yl)methyl)- 1-((3-chloro-...)
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM392573(N-((1-aminoisoquinolin-6-yl)methyl)- 1-((3-chloro-...)
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent