BDBM394291 N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanocyclopropyl]phenyl]- 1-[2-(dimethylamino)-2-oxo- ethyl]pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3-carboxamide::US10307426, Example 1

SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)[C@@H]1C[C@H]1C#N

InChI Key InChIKey=INLBJLWIABKOJJ-HOTGVXAUSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394291   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394291(N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanoc...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394291(N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanoc...)
Affinity DataKi:  0.610nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent