BDBM423269 US10501451, Example 2, P-1::US10501451, Example 2, P-2::US10954225, Example 2,P-2

SMILES Cc1ccc(CN2OCC(N3CCC(CC3)c3ccc(O)cc3)C2=O)cc1

InChI Key InChIKey=FPIZPFGNSFRUKW-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423269   

TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423269(US10501451, Example 2, P-1 | US10501451, Example 2...)
Affinity DataKi:  2.79nMAssay Description:Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423269(US10501451, Example 2, P-1 | US10501451, Example 2...)
Affinity DataKi:  2.79nMAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423269(US10501451, Example 2, P-1 | US10501451, Example 2...)
Affinity DataKi:  112nMAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423269(US10501451, Example 2, P-1 | US10501451, Example 2...)
Affinity DataKi:  112nMAssay Description:Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent