BDBM430126 4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide::US10538491, Compound 52

SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1

InChI Key InChIKey=SSSNPJKQBYVHBV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 430126   

TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University

US Patent
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50:  66nMAssay Description:Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu3R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50:  78nMAssay Description:Negative allosteric modulation of mGlu2R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu4R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu6R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu7R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu8R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu5R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed