BDBM433075 5-ethyl-N-((1R,3r,5S)-8-(((1-(4,4,4- trifluorobutyl)piperidin-4- yl)methyl)sulfonyl)-8- azabicyclo[3.2.1]octan-3-yl)isoxazole-3- carboxamide::US10577363, Compound 779

SMILES CCc1cc(no1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)CC1CCN(CCCC(F)(F)F)CC1

InChI Key InChIKey=JLGDZQUCUKBBGC-REPLKXPHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433075   

TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM433075(5-ethyl-N-((1R,3r,5S)-8-(((1-(4,4,4- trifluorobuty...)
Affinity DataIC50:  1.20nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent