BDBM446455 (R)-1-((7-cyano-2-(3′-(7-(((S)-3-hydroxy-3-methylpyrrolidin-1-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic Acid::US10669271, Example 8
SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@H](C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@](C)(O)C3)cc2n1
InChI Key InChIKey=RBIRYSWFJHPWOM-KGAOLOCMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 446455
Affinity DataIC50: <10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:U2OS/PD-L1 cells (DiscoveRx Corporation) were maintained in McCoy's 5A medium with addition of 10% FBS, 0.25 μg/ml Puromycin. After removing...More data for this Ligand-Target Pair