BDBM452523 1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- furan-3-yl)-1,2,4- oxadiazol-5-yl)methyl)- 7-methyl-1,7-dihydro- 6H-purin-6-one::US10710994, Example 1::US10710994, Example 132::US10710994, Example 5::US10710994, Example 6::US10710994, Example 70

SMILES Cn1cnc2ncn(Cc3nc(no3)[C@@H]3CO[C@H](C3)c3ccc(Cl)cc3)c(=O)c12

InChI Key InChIKey=UGLQOTZNBCEHHB-GXTWGEPZSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 452523   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  3.69nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  0.880nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  17.6nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  3.10nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  18.3nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  4.30nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  1.20nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  7.43nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  2.20nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  7.40nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  4.71nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent