BDBM454225 (Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-(3-(N-methylsulfamoyl)phenyl)- 1H-indole-5-carboxylic acid::US10717733, Compound 18::US11098045, Compound 18

SMILES CNS(=O)(=O)c1cccc(c1)-c1c(C)n(C\C(F)=C\CN)c2ccc(cc12)C(O)=O

InChI Key InChIKey=PCPBDUMNYRZIDJ-PXNMLYILSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 454225   

TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: >300nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: <300nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: >3.00E+3nMAssay Description:Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxidase, copper-c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: >3.00E+3nMAssay Description:Mao-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: >300nMAssay Description:LOX: The assay was developed using either 384 or 96 well format. Briefly, in a standard 384 well plate assay 25 μL of a dilution of any of the i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: <300nMAssay Description:LOX: The assay was developed using either 384 or 96 well format. Briefly, in a standard 384 well plate assay 25 μL of a dilution of any of the i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: >3.00E+3nMAssay Description:Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxidase, copper-c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Pharmaxis

US Patent
LigandPNGBDBM454225((Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-2- methyl-3-...)
Affinity DataIC50: >3.00E+3nMAssay Description:MAO-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent