BDBM457753 8-Amino-N-(1- (hydroxymethyl)-2- oxabicyclo[2.1.1]hexan- 4-yl)-3-(2-methyl-5- (1,1,1-trifluoro-2- hydroxypropan-2-::US10738057, Example 279::US11225486, Example 279

SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C(=O)NC12CC(CO)(C1)OC2)C(C)(O)C(F)(F)F

InChI Key InChIKey=BIHROWIPJZQHCY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 457753   

LigandPNGBDBM457753(8-Amino-N-(1- (hydroxymethyl)-2- oxabicyclo[2.1.1]...)
Affinity DataIC50: <100nMAssay Description:PI3K-γ: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from PerkinElmer (Waltham, Mass.)....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM457753(8-Amino-N-(1- (hydroxymethyl)-2- oxabicyclo[2.1.1]...)
Affinity DataIC50: <500nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM457753(8-Amino-N-(1- (hydroxymethyl)-2- oxabicyclo[2.1.1]...)
Affinity DataIC50: <100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM457753(8-Amino-N-(1- (hydroxymethyl)-2- oxabicyclo[2.1.1]...)
Affinity DataIC50: <500nMAssay Description:PI3Kδ: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from PerkinElmer (Waltham, Mass.). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent