BDBM457754 US10738057, Example 283::US11225486, Example 283

SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C(=O)NCC1(CCC1)C#N)C(C)(O)C(F)(F)F

InChI Key InChIKey=OTZYLQXEUUJHEZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 457754   

LigandPNGBDBM457754(US10738057, Example 283 | US11225486, Example 283)
Affinity DataIC50: <100nMAssay Description:PI3K-γ: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from PerkinElmer (Waltham, Mass.)....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM457754(US10738057, Example 283 | US11225486, Example 283)
Affinity DataIC50: <100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM457754(US10738057, Example 283 | US11225486, Example 283)
Affinity DataIC50: <100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM457754(US10738057, Example 283 | US11225486, Example 283)
Affinity DataIC50: <100nMAssay Description:PI3Kδ: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from PerkinElmer (Waltham, Mass.). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent