BDBM4620 Anilinoquinazoline deriv. 3::N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(Nc3ccc(Cl)cc3)c2cc1OC

InChI Key InChIKey=LHGGYEWCVWOGFX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4620   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4620(Anilinoquinazoline deriv. 3 | N-(4-chlorophenyl)-6...)
Affinity DataIC50:  1.10E+4nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chaminade University Of Honolulu

Curated by ChEMBL
LigandPNGBDBM4620(Anilinoquinazoline deriv. 3 | N-(4-chlorophenyl)-6...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorption by ELISA assay in presence of 20 uM ATPChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4620(Anilinoquinazoline deriv. 3 | N-(4-chlorophenyl)-6...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chaminade University Of Honolulu

Curated by ChEMBL
LigandPNGBDBM4620(Anilinoquinazoline deriv. 3 | N-(4-chlorophenyl)-6...)
Affinity DataIC50:  800nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed