BDBM467354 (R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(2-methyl-4- phenoxyphenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8- triazaacenaphthylene-2-carboxamide;::US10800792, Example 5::US10822348, Example 5

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 467354   

TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467354((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(2-methyl...)
Affinity DataIC50:  7.94nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467354((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(2-methyl...)
Affinity DataIC50:  15.8nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467354((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(2-methyl...)
Affinity DataIC50:  398nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467354((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(2-methyl...)
Affinity DataIC50:  7.94nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent