BDBM473173 US10844038, Example 42::US10844038, Example 45::trans 3-((4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1,2-dithiolan-4-ol

SMILES Nc1ncnc2n(CC3SSCC3O)nc(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key InChIKey=UORAPQCBWYIISR-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 473173   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM473173(US10844038, Example 42 | US10844038, Example 45 | ...)
Affinity DataIC50:  750nMAssay Description:IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM473173(US10844038, Example 42 | US10844038, Example 45 | ...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM473173(US10844038, Example 42 | US10844038, Example 45 | ...)
Affinity DataKd:  5.50E+3nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM473173(US10844038, Example 42 | US10844038, Example 45 | ...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM473173(US10844038, Example 42 | US10844038, Example 45 | ...)
Affinity DataKd:  750nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent