BDBM474012 N-(5-{2-[(1S)-1-Cyclopropylethyl]-1-oxo-7-[(2,2,2- trifluoroethyl)sulfamoyl]-2,3-dihydro-1H-isoindol-5-yl}-4-methyl-1,3- thiazol-2-yl)acetamide::US10858355, Example 20
SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NCC(F)(F)F)-c1sc(NC(C)=O)nc1C
InChI Key InChIKey=DMLJCQPTINGHQR-NSHDSACASA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 474012
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair