BDBM478931 2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 17

SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C

InChI Key

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478931   

TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478931(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478931(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataIC50:  7.96E+3nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478931(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataIC50:  81nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478931(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataIC50:  590nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent