BDBM490778 US10968242, Example 7 Peak 1::US10968242, Example 7 Peak 2

SMILES Cc1nc2n(cnc2c(=O)[nH]1)[C@@H]1C[C@@H]2OP(S)(=O)O[C@@H]3[C@@H](COP(S)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12

InChI Key

Data  2 KI  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 490778   

TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKi:  44nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKi:  107nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKd:  416nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKd:  98nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKd:  1.04E+3nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKd:  1.89E+3nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent