BDBM492834 7-((2,5-difluoro-4-(1,2,4- oxadiazol-3-yl)benzyl)thio)- 3H-[1,2,3]triazolo[4,5-b] pyridin-5-amine::US10981879, Example 28

SMILES Nc1cc(SCc2cc(F)c(cc2F)-c2ncon2)c2nn[nH]c2n1

InChI Key InChIKey=UODILQYIMFHDBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 492834   

TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492834(7-((2,5-difluoro-4-(1,2,4- oxadiazol-3-yl)benzyl)t...)
Affinity DataIC50:  10nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog #A12222) which ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492834(7-((2,5-difluoro-4-(1,2,4- oxadiazol-3-yl)benzyl)t...)
Affinity DataIC50:  80nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent