BDBM50001750 CHEMBL3238424

SMILES OC(=O)c1cccc(NCc2cccc(c2)-n2ccc3c(cccc23)-c2ccc(cc2)C(F)(F)F)c1

InChI Key InChIKey=XPJOGIGKCTXMJB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50001750   

TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50001750(CHEMBL3238424)
Affinity DataIC50:  2.64E+4nMAssay Description:Inhibition of C-terminal GST-tagged human G9a-mediated-methylation of histone3 expressed in Escherichia coli BL21(DE3) by MALDI-TOF mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50001750(CHEMBL3238424)
Affinity DataIC50:  2.25E+4nMAssay Description:Inhibition of SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin after 5 mins by scintillation proximity assay in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50001750(CHEMBL3238424)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of 100 nM SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin at 15 to 50 uM after 5 mins by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50001750(CHEMBL3238424)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of 10 nM SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin at 15 to 50 uM after 5 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50001750(CHEMBL3238424)
Affinity DataIC50:  2.25E+4nMAssay Description:Inhibition of 50 nM SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin at 15 to 50 uM after 5 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50001750(CHEMBL3238424)
Affinity DataIC50:  9.93E+3nMAssay Description:Inhibition of methyl-transferase activity in GST-tagged recombinant SET7/9 (unknown origin) expressed in Escherichia coli BL21 using H3(1-20)-cys-bio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed