BindingDB BDBM50001955 (-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol(APO)::(Apomorphine) 6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol ((R)-apomorphine)::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (apomorphine)::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol(apomorphine)::(apomorphine)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol ((R)-apomorphine)::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol((R)-apomorphine)::APOKYN::APOMORPHINE::APOMORPHINE HYDROCHLORIDE::APOMORPHINE6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::CHEMBL53

BDBM50001955 (-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol(APO)::(Apomorphine) 6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol ((R)-apomorphine)::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (apomorphine)::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol(apomorphine)::(apomorphine)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol ((R)-apomorphine)::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol((R)-apomorphine)::APOKYN::APOMORPHINE::APOMORPHINE HYDROCHLORIDE::APOMORPHINE6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::CHEMBL53

SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31

InChI Key InChIKey=VMWNQDUVQKEIOC-CYBMUJFWSA-N

Data 138 KI 76 IC50 8 Kd 30 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50001955

D(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 7.20nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details PubMed PDB

3D Structure (crystal)

D(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 8nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details PubMed PDB

3D Structure (crystal)

D(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 8.60nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details PubMed PDB

3D Structure (crystal)

D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 40nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 43nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 44nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 51nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

D(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 53nMAssay Description:Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

Ki: 200nMAssay Description:Compound was tested for inhibition of [3H]spiroperidol binding against Dopamine receptor D2More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 24nMAssay Description:Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]-spiperone as ligand...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article

D(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 384nMAssay Description:Compound was evaluated in vitro for binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]-SCH-23,390More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PDB

3D Structure (crystal)

D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 24nMAssay Description:Compound was evaluated in vitro for binding affinity to Dopamine receptor D2 in rat striatal membranes using D2 antagonist [3H]-spiperoneMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article

D(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 384nMAssay Description:Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PDB

3D Structure (crystal)

D(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 238nMAssay Description:In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PDB

3D Structure (crystal)

D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 24nMAssay Description:Displacement of [3H]spiperone from rat striatal Dopamine receptor D2More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article

D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 1.70nMAssay Description:Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine agonist [3H]N-propylnorapomorphine ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 7.75E+3nMAssay Description:Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 1.35E+3nMAssay Description:Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 15nMAssay Description:Noncompetitive Iinhibitory activity against human liver DHPR enzymeMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Metalloproteinase inhibitor 3(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: >1.00E+4nMAssay Description:Noncompetitive Inhibitory activity against rat striatal synaptosomal DHPR enzymeMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 430nMAssay Description:In vitro inhibitory activity against alpha-2 adrenergic receptor from rat brain minus cerebellum using [3H]clonidine as radioligandMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

Metalloproteinase inhibitor 3(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 4.50E+3nMAssay Description:In vitro inhibitory activity against serotonin receptor from rat frontal cortex using [3H]spiperone as radioligandMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 100nMAssay Description:Inhibition of [3H]haloperidol binding to Dopamine receptor in calf caudate nuclei.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 5nMAssay Description:Inhibition of [3H]dopamine binding to Dopamine receptor in calf caudate nuclei.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 830nMAssay Description:Inhibitory binding activity against dopamine receptor using [3H]ADTN as the radioligand in striatal tissue of calf brain.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 8.70E+3nMAssay Description:Inhibitory binding activity against dopamine receptor using [3H]spiperone as the radioligand in striatal tissue of calf brain.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 4.90nMAssay Description:Tested for binding to dopamine receptor using [3H]- ADTN as radioligand in calf caudate nucleus homogenates.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 1nMAssay Description:Tested for binding to dopamine receptor using [3H]apomorphine as radioligand in calf caudate nucleus homogenates.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 8.60nMAssay Description:Tested for binding to dopamine receptor using [3H]spiroperidol as radioligand in calf caudate nucleus homogenates.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 7.75E+3nMAssay Description:In vitro inhibitory activity was evaluated against,[3H]WB 4101 whole rat brain alpha 1-adrenoceptorMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 15nMAssay Description:In vitro inhibitory activity was evaluated against [3H]dopamine (DA) calf caudate dopamine receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 1.35E+3nMAssay Description:In vitro inhibitory activity was evaluated against [3H]spiperone calf caudate (SPC) dopamine receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 430nMAssay Description:In vitro inhibitory activity was evaluated against,[3H]clonidine (Clon) rat brain minus cerebellum Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

Metalloproteinase inhibitor 3(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 4.50E+3nMAssay Description:In vitro inhibitory activity was evaluated against,[3H]spiperone rat frontal cortex (SPFC) serotonin receptorMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

Metalloproteinase inhibitor 3(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: >1.00E+4nMAssay Description:In vitro inhibitory activity was evaluated against,[3H]serotonin (5-HT) whole rat brain serotonin receptorMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed

D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)

IC50: 1.70nMAssay Description:In vitro agonist binding affinity was determined by displacing the [3H]N-propylnorapomorphine ([3H]NPA) in rat striatal Dopamine receptor D2More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article

Filter my 252 hits

Targets 43▿
- D(2) dopamine receptor 95
- D(1A) dopamine receptor 43
- D(3) dopamine receptor 12
- D(1A)/D(2) dopamine receptor 12
- D(4) dopamine receptor 11
- D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor 10
- 5-hydroxytryptamine receptor 1A 8
- Sigma non-opioid intracellular receptor 1 5
- D(1B) dopamine receptor 4
- 5-hydroxytryptamine receptor 7 4
- Metalloproteinase inhibitor 3 4
- Alpha-1A adrenergic receptor 3
- Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 3
- E3 ubiquitin-protein ligase Mdm2 3
- 5-hydroxytryptamine receptor 2A 3
- Dopamine receptor D4 2
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 2
- 5-hydroxytryptamine receptor 2C 2
- Bile salt export pump 2
- Sodium-dependent serotonin transporter 1
- Solute carrier family 22 member 1 1
- Alpha-2B adrenergic receptor 1
- Zinc finger protein mex-5 1
- Alpha-1D adrenergic receptor 1
- Alpha-2A adrenergic receptor [16-465] 1
- Potassium voltage-gated channel subfamily H member 2 1
- Beta-2 adrenergic receptor 1
- Procathepsin L 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- Alpha-2C adrenergic receptor 1
- POsterior Segregation 1
- Alpha-1B adrenergic receptor 1
- ATP-binding cassette sub-family C member 2 1
- Beta-1 adrenergic receptor 1
- M18 aspartyl aminopeptidase 1
- Histamine H1 receptor 1
- Nicotinic acetylcholine receptor 1
- 5-hydroxytryptamine receptor 1B 1
- 5-hydroxytryptamine receptor 2B 1
- 5-hydroxytryptamine receptor 3A 1
- 5-hydroxytryptamine receptor 1D 1
- Alpha-2A adrenergic receptor 1
- ...
Publications 50▿
- J Pharmacol Exp Ther 303: 791-804 (2002) 21
- J Med Chem 49: 7450-65 (2006) 8
- ACS Med Chem Lett 11: 385-392 (2020) 8
- NIDA Res Monogr 178: 440-66 (1998) 7
- Mol Pharmacol 12: 800-12 (1976) 7
- J Med Chem 28: 367-75 (1985) 6
- J Med Chem 28: 1540-2 (1985) 6
- J Med Chem 47: 3853-64 (2004) 6
- J Med Chem 37: 3523-33 (1994) 5
- Bioorg Med Chem Lett 30: (2020) 5
- ACS Med Chem Lett 2: 189-194 (2011) 5
- Toxicol Sci 136: 216-41 (2013) 4
- J Med Chem 43: 3005-19 (2000) 4
- Bioorg Med Chem 16: 4563-8 (2008) 4
- J Med Chem 35: 4683-9 (1993) 3
- Eur J Med Chem 46: 2992-9 (2011) 3
- Eur J Med Chem 55: 255-61 (2012) 3
- J Med Chem 33: 311-7 (1990) 3
- Bioorg Med Chem Lett 1: 189-192 (1991) 3
- J Med Chem 25: 990-2 (1982) 3
- J Med Chem 43: 1339-49 (2001) 3
- Bioorg Med Chem 17: 4756-62 (2009) 3
- Nature 350: 610-4 (1991) 3
- J Med Chem 39: 3503-13 (1996) 3
- J Med Chem 39: 3491-502 (1996) 3
- J Med Chem 33: 1800-5 (1990) 3
- J Med Chem 38: 647-58 (1995) 3
- J Med Chem 33: 39-44 (1990) 3
- Bioorg Med Chem Lett 3: 639-644 (1993) 3
- Bioorg Med Chem Lett 27: 2571-2574 (2017) 3
- J Med Chem 44: 1337-40 (2001) 3
- Bioorg Med Chem 16: 3438-44 (2008) 2
- J Med Chem 29: 1904-12 (1986) 2
- J Med Chem 33: 2408-12 (1990) 2
- Bioorg Med Chem 21: 4143-50 (2013) 2
- J Med Chem 39: 850-9 (1996) 2
- Arzneimittelforschung 42: 224-30 (1992) 2
- J Med Chem 35: 1076-92 (1992) 2
- Bioorg Med Chem Lett 17: 6691-6 (2007) 2
- J Med Chem 33: 445-50 (1990) 2
- J Med Chem 32: 1198-201 (1989) 2
- J Med Chem 53: 2510-20 (2010) 2
- J Med Chem 33: 600-7 (1990) 2
- Bioorg Med Chem Lett 11: 883-6 (2001) 2
- Life Sci 35: 1885-93 (1984) 2
- Bioorg Med Chem Lett 1: 539-544 (1991) 2
- J Med Chem 23: 977-80 (1980) 2
- J Med Chem 31: 688-91 (1988) 2
- J Med Chem 25: 1442-6 (1982) 2
- Nature 347: 146-51 (1990) 2
- ...
Institutions 28▿
- TBA 36
- Institut De Recherches Servier 21
- Uppsala University 15
- Abbott Laboratories 14
- University Of Tartu 11
- Duke University 8
- Northeastern University 8
- Warner-Lambert 7
- Sri International 7
- Harvard Medical School 5
- Parke-Davis Pharmaceutical Research 5
- City University Of New York 5
- University Of Debrecen 4
- U. 109 4
- Amgen 4
- University Of Texas 4
- Kyoto University 3
- National Institute On Drug Abuse 3
- University of Toronto 3
- Schering-Plough 2
- Eli Lilly 2
- Upjohn Laboratories 2
- University Of Crete 2
- Pfizer 2
- Va Medical Center 2
- University Centre For Pharmacy 2
- University Of Camerino 2
- Neurosearch Sweden 2
- ...
Affinity: 0.40 to 3.0E+5 nM▿
- Ki 138
- IC50 76
- Kd 8
- EC50 30
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1