BDBM50012244 2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid::2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid(DMPDDF)::CHEMBL25889
SMILES Cc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
InChI Key InChIKey=PMTUUSDTAKQWQJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50012244
Affinity DataKi: 4.80nMAssay Description:Inhibition of Thymidylate synthase of E. coli (Ki)More data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Inhibition of human Thymidylate synthase (Ki)More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of pure human thymidyllate synthase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University Of South Alabama
Curated by ChEMBL
University Of South Alabama
Curated by ChEMBL
Affinity DataIC50: >1.70E+4nMAssay Description:Inhibition of thymidyllate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University Of South Alabama
Curated by ChEMBL
University Of South Alabama
Curated by ChEMBL
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of AICAR formyltransferase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro inhibitory activity against thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University Of South Alabama
Curated by ChEMBL
University Of South Alabama
Curated by ChEMBL
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of AICAR formyltransferase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of GAR formyltransferase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of thymidyllate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University Of South Alabama
Curated by ChEMBL
University Of South Alabama
Curated by ChEMBL
Affinity DataIC50: >1.70E+4nMAssay Description:Inhibition of GAR formyltransferase in Lactobacillus caseiMore data for this Ligand-Target Pair