BDBM50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester

SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12

InChI Key InChIKey=BLGXFZZNTVWLAY-SCYLSFHTSA-N

Data  304 KI  18 IC50  8 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50013515   

TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against Alpha-1B adrenergic receptor from hamster clones.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against Alpha-1D adrenergic receptor, from human clones.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  3.60nMAssay Description:Compound was evaluated for inhibition of binding of [3H]-yohimbine to Alpha-2 adrenergic receptor in bovine pinealMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(PIG)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  4.40nMAssay Description:Compound was evaluated for inhibition of binding of [3H]-yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity against Alpha-1B adrenergic receptor from human cloneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  52nMAssay Description:Binding affinity against Alpha-1D adrenergic receptor, from rat clones.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed