BDBM50026917 8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione::8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione::8-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::8-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione(BMY-7378)::BMY 7378::BMY-7378::CHEMBL1256934::CHEMBL13647::CHEMBL543741
SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
InChI Key InChIKey=AYYCFGDXLUPJAQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 93 hits for monomerid = 50026917
Affinity DataKi: 0.370nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cell membranes after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.372nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in human HeLa cell membranes after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 0.372nMAssay Description:Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in human HeLa cells incubated for 30 mins by radioligand competition ...More data for this Ligand-Target Pair
Affinity DataKi: 0.372nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.778nMAssay Description:Binding affinity towards human Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...More data for this Ligand-Target Pair
Affinity DataKi: 0.933nMAssay Description:Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.959nMAssay Description:In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair
Affinity DataKi: 1.05nMAssay Description:Binding affinity to adrenergic Alpha-1D receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.26nMAssay Description:Displacement of [3H]-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.26nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.26nMAssay Description:Displacement [3H]8-OH-DPAT of human cloned 5HT1A receptor expressed in human HeLa cells by rapid filtration techniqueMore data for this Ligand-Target Pair
Affinity DataKi: 1.29nMAssay Description:Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.29nMAssay Description:Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueMore data for this Ligand-Target Pair
Affinity DataKi: 1.29nMAssay Description:Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoreceptor expressed in CHO cells after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.29nMAssay Description:Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HeLa cell membranes after 30 mins by TopCount liquid scintillation ...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha-1d adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scin...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competit...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibitory constant value against the 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adren...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity for human Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Binding affinity to human 5-HT1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Affinity DataKi: 2.40nMAssay Description:Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Binding affinity for rat Dopamine receptor D3More data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:In vitro binding affinity at human Alpha-1D adrenergic receptor.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Affinity DataKi: 8.20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]-8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataKi: 8.60nMAssay Description:Binding affinity to the adrenergic receptor alpha-1D of rat aortaMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity for human Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 42.7nMAssay Description:Binding affinity to adrenergic alpha1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Binding affinity towards bovine Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Antagonistic affinity against rat striatum Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 49nMAssay Description:Displacement of [3H]spiperone from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 50.1nMAssay Description:Binding affinity to adrenergic Alpha-1B receptorMore data for this Ligand-Target Pair
Affinity DataKi: 69nMAssay Description:Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Affinity DataKi: 79nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Affinity DataKi: 79.4nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
Affinity DataKi: 94nMAssay Description:Binding affinity towards human Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 112nMAssay Description:In vitro functional activity at Alpha-1B adrenergic receptor in rat spleenMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Binding affinity for human Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair