BDBM50027084 Melatonan

SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O

InChI Key InChIKey=JDKLPDJLXHXHNV-UHFFFAOYSA-N

Data  13 KI  28 IC50  54 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 95 hits for monomerid = 50027084   

TargetMelanocyte-stimulating hormone receptor(Mouse)
University of Cergy-Pontoise

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.0300nMAssay Description:Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC1R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at mouse melanocortin-4 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 1 expressed in human T-Rex-293 cells assessed as stimulation of intracellular cAMP accumulation incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.0570nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.0600nMAssay Description:Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.0617nMAssay Description:Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.0617nMAssay Description:Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  0.112nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using low doxycycline assessed as stimulation of intracellular c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.120nMAssay Description:Antagonist activity at human MC4R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  0.132nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  0.132nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocortin receptor 3(Mouse)
University of Cergy-Pontoise

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.180nMAssay Description:Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Cergy-Pontoise

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.190nMAssay Description:Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.204nMAssay Description:Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Mouse)
University of Cergy-Pontoise

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.220nMAssay Description:Agonist activity at mouse melanocortin-1 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.270nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.347nMAssay Description:Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Mouse)
University of Cergy-Pontoise

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.350nMAssay Description:Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  0.456nMAssay Description:Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC4R expressed in HEK293 cell membranes incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  0.457nMAssay Description:Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC4R expressed in HEK293 cell membranes incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Cergy-Pontoise

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  0.570nMAssay Description:Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1nMAssay Description:Activity at human MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1 receptor expressed in HEK293 cells by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.10nMAssay Description:Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 4 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.20nMAssay Description:Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.20nMAssay Description:Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 1 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMelanocortin receptor 5(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
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