BDBM50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2
SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
InChI Key InChIKey=WHNFPRLDDSXQCL-UAZQEYIDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 156 hits for monomerid = 50029747
Affinity DataKi: 1.5nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC1 receptor expressed in BHK570 cells after 90 mins in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 8.60nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.30nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human wild type MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from MC4 receptor after 2 hrs by gamma counting in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 116nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 137nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 231nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 257nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Effective concentration for the effect of Melanocortin 1 receptor in the frog skin.More data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Evaluated for agonist at cloned mammalian Melanocortin 1 receptor in frog (Rana pipiens) skin assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0910nMAssay Description:Evaluated for agonist activity against human Melanocortin 1 receptor using hMC1-R assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.669nMAssay Description:Evaluated for agonist activity at cloned Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)More data for this Ligand-Target Pair
Affinity DataEC50: 6.70nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
Affinity DataEC50: 8.10nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.650nMAssay Description:Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assess...More data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Effective concentration towards human melanocortin-4 receptor mediated cAMP accumulation in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 6.70nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 1 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 4 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataEC50: 8.10nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataEC50: 0.670nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
Affinity DataIC50: 118nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-a...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at mouse MC1 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.220nMAssay Description:Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.510nMAssay Description:Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayMore data for this Ligand-Target Pair