BDBM50033538 6-{[Methyl-(3,4,5-trimethoxy-benzyl)-amino]-methyl}-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL122704

SMILES COc1cc(CN(C)CC2CCc3nc(N)nc(N)c3C2)cc(OC)c1OC

InChI Key InChIKey=ZONAULPBABNWOR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50033538   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033538(6-{[Methyl-(3,4,5-trimethoxy-benzyl)-amino]-methyl...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033538(6-{[Methyl-(3,4,5-trimethoxy-benzyl)-amino]-methyl...)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033538(6-{[Methyl-(3,4,5-trimethoxy-benzyl)-amino]-methyl...)
Affinity DataIC50:  330nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed