BDBM50039177 3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-bicyclo[3.2.1]octane; hydrochloride::CHEMBL119664::CHEMBL541825

SMILES CN1C2CCC1CC(C2)OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key InChIKey=DAAKBMHWKLVSKY-UHFFFAOYSA-N

Data  16 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50039177   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  17.5nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]WIN-35428 binding to the dopamine transporter in rat caudate putamen tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  20nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  20nMAssay Description:Binding affinity for dopamine transporter was determined in vitro in rat brain using [3H]WIN-35428 s radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  23.4nMAssay Description:Ability of compound to inhibit dopamine uptake of receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  40.6nMAssay Description:Displacement of [3H]pirenzepine from M1 receptor in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  47.9nMAssay Description:Binding affinity for muscarinic m1 receptor was determined in vitro in rat brain using [3H]pirenzepine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  47.9nMAssay Description:Binding affinity at muscarinic M1 receptor in rat brain by [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  220nMAssay Description:Binding affinity at dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  1.64E+3nMAssay Description:Binding affinity at serotonin transporter in rat brain by [3H]-citalopram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  1.64E+3nMAssay Description:Binding affinity for serotonin transporter was determined in vitro in rat brain using [3H]citalopram as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  1.64E+3nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  2.98E+3nMAssay Description:Binding affinity for norepinephrine transporter in rat brain using [3H]-nisoxatine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  2.98E+3nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  2.98E+3nMAssay Description:Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  75nMAssay Description:Inhibition of [3H]dopamine uptake in rat caudate putamen tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039177(3-[Bis-(4-chloro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  23.4nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed