BDBM50039824 CHEMBL81728::N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-ethyl}-4-fluoro-benzamide
SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1cccc2OCCOc12
InChI Key InChIKey=GTEYGWXMYSXCRZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50039824
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Binding affinity to human 5-HT1A receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.295nMAssay Description:Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human D4 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Binding affinity to human 5-HT1D receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Binding affinity to human alpha 1A adrenergic receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 46nMAssay Description:Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataEC50: 0.851nMAssay Description:Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataEC50: 0.780nMAssay Description:In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataEC50: 0.955nMAssay Description:Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)More data for this Ligand-Target Pair