BDBM50040806 CHEMBL3361254

SMILES NC(=O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@@H](CC4)N4CCOCC4)c3c12

InChI Key InChIKey=VZOLINZYKOLXAC-RBSFLKMASA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50040806   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataKi:  7.5nMAssay Description:Inhibition of N-terminal GST-fused full-length human IRAK4 (1 to 460 amino acids) assessed as reduction in phosphorylated substrates by Caliper assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataIC50:  22nMAssay Description:Inhibition of CDK8 in human A549 cells by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed