BDBM50041735 1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-phenyl)-cyclopentylmethyl]-urea; hydrochloride::CHEMBL46423::CHEMBL542103

SMILES CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(CCCC1)c1ccc(cc1)N(C)C

InChI Key InChIKey=PKKNCEXEVUFFFI-UHFFFAOYSA-N

Data  5 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50041735   

TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against ACAT was determined in rabbit intestinal microsome from cholesterol-fed animalsMore data for this Ligand-Target Pair
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50:  52nMAssay Description:Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbitsMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50:  368nMAssay Description:Inhibition of human SOAT2 expressed in mouse AC29 cellsMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human SOAT1 expressed in mouse AC29 cellsMore data for this Ligand-Target Pair
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50:  37nMAssay Description:Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbitsMore data for this Ligand-Target Pair