BDBM50042947 1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone::1-(4-chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one::4'-chloro-3-methoxy-4-hydroxychalcone::CHEMBL126657::Chalcone 4

SMILES COc1cc(\C=C\C(=O)c2ccc(Cl)cc2)ccc1O

InChI Key InChIKey=KCTNGNPVURILGU-KRXBUXKQSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50042947   

TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042947(1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataKi:  53nMAssay Description:Inhibition of EGFP-tagged human CXCR4 expressed in HEK293 cells assessed as inhibition of CXCL12-TR binding incubated for 5 mins prior to CXCL12-TR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromal cell-derived factor 1(Homo sapiens (Human))
Umr7200 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50042947(1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataKi:  53nMAssay Description:Binding affinity to Texas Red-labelled CXCL12 (unknown origin) assessed as inhibition of CXCL12-Texas Red binding to EGFP-labeled human CXCR4 express...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042947(1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataIC50:  8.90E+3nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromal cell-derived factor 1(Homo sapiens (Human))
Umr7200 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50042947(1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataIC50:  1.50E+5nMT: 2°CAssay Description:Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042947(1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article