BDBM50045672 3-[6-(5-Butyl-pyridin-2-ylmethoxy)-1-(4-chloro-benzyl)-4-methyl-4,5-dihydro-1H-3-thia-1-aza-acenaphthylen-2-yl]-2,2-dimethyl-propionic acid::CHEMBL329529

SMILES CCCCc1ccc(COc2ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)C(O)=O)c4SC(C)Cc2c34)nc1

InChI Key InChIKey=DNMJJTUXOLEAAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50045672   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045672(3-[6-(5-Butyl-pyridin-2-ylmethoxy)-1-(4-chloro-ben...)
Affinity DataIC50:  42nMAssay Description:In vitro inhibition of LTB4 biosynthesis in [Ca2+]-ionophore-activated human polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045672(3-[6-(5-Butyl-pyridin-2-ylmethoxy)-1-(4-chloro-ben...)
Affinity DataIC50:  500nMAssay Description:In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed