BDBM50050652 CHEMBL47146::PD-160946::[(R)-2-(2-Fluoro-phenyl)-1-methyl-1-(7-ureido-heptylcarbamoyl)-ethyl]-carbamic acid (S)-2-methyl-1-phenyl-propyl ester

SMILES CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1

InChI Key InChIKey=ZAYADERDILOEBG-ABYGYWHVSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50050652   

TargetSubstance-K receptor(HAMSTER)
TBA

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  1.50E+3nMAssay Description:Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]n...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuromedin-K receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for binding affinity towards Tachykinin receptor 3 binding sites in guinea pig cortical membranes using [125I]-[MePhe7]-Neurokini...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(HAMSTER)
TBA

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I]-[MePhe7]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  16nMAssay Description:Binding affinity towards human Tachykinin receptor 3 stably expressed in CHO cells using [125I][MePhe7]-NKB as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuromedin-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against cloned human Tachykinin receptor 3 in CHO cells labeled with [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Rattus norvegicus)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  83nMAssay Description:Inhibitory activity against cloned human Tachykinin receptor 3 in CHO cells labeled with [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50050652(CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)...)
Affinity DataIC50:  2.20E+3nMAssay Description:Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article