BDBM50051915 CHEMBL32708::N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine::N6-(2,5-dimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine

SMILES COc1ccc(OC)c(CNc2cnc3nc(N)nc(N)c3c2)c1

InChI Key InChIKey=CVKTUICDKSUYDI-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50051915   

TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity of the compound against recombinant ec dihydrofolate reductase(in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory activity of the compound against recombinant lc dihydrofolate reductase(in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity of the compound against Toxoplasma gondii dihydrofolate reductase (in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase(in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  350nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  350nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  350nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051915(CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity of the compound against recombinant sf dihydrofolate reductase(in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed