BDBM50053306 CHEMBL3330260

SMILES CCc1cccc(CC)c1NC(=O)Nc1ccc2[nH]nc(-c3cccc(c3)S(N)(=O)=O)c2c1

InChI Key InChIKey=FMRUHQLKCRUMNL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50053306   

TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  130nMAssay Description:Inhibition of GST-tagged human PLK4 (1-391 residues) phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Aurora B (unknown origin) by FRET-based homogenous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  410nMAssay Description:Inhibition of CHK2 (unknown origin) by FRET-based homogenous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP3A4 in supersomes (unknown origin) using Dibenzylfluorescein as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in supersomes (unknown origin) using AMMC as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CYP2C19 in supersomes (unknown origin) using MFC as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of SUMO-tagged human TTK (1-275 residues) compound pre-incubated for 15 mins prior ATP addition by MBP-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP2C9 in supersomes (unknown origin) using MFC as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in supersomes (unknown origin) using CEC as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053306(CHEMBL3330260)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP3A4 in supersomes (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed