BDBM50054587 (Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide::Alpha-cyano-beta-hydroxy enamide, 6::CHEMBL141195

SMILES O=C(Nc1ccc(cc1)C#N)C(C#N)C(=O)C1CC1

InChI Key InChIKey=GSSLQBZZKKOMAF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50054587   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Novartis Pharma

LigandPNGBDBM50054587((Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hyd...)
Affinity DataIC50:  600nMAssay Description:Spectrophotometric assay using crude human, recombinant DHODHase.More data for this Ligand-Target Pair
In DepthDetails
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM50054587((Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hyd...)
Affinity DataIC50:  7.08E+5nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50054587((Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hyd...)
Affinity DataIC50:  42nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50054587((Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hyd...)
Affinity DataIC50:  53nMAssay Description:Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed